This book discusses the role of genetic polymorphism in susceptibility to cancers. The book explores the understanding of differences between the genetic polymorphisms and mutations.It reviews the mechanisms underlying the effect of polymorphism in genes encoding proteins that play an essential role in metabolism, signal transduction, cell cycle, and DNA repair mechanisms. Further, it investigates various techniques that are used for analyzing the genetic polymorphisms. The book contains many chapters which summarize the importance of genetic information obtained from polymorphism-based pharmaco-genetic tests to predict better drug response and life-threatening adverse reactions to chemotherapeutic agents, help in understanding of the impact of SNPs on gene function, and gives overview of the different SNP databases for examination. This book, therefore, serves as an essential guidebook for independent researchers as well as institutions working in this specialised field.

This book discusses the role of genetic polymorphism in susceptibility to cancers. The book explores the understanding of differences between the genetic polymorphisms and mutations.It reviews the mechanisms underlying the effect of polymorphism in genes encoding proteins that play an essential role in metabolism, signal transduction, cell cycle, and DNA repair mechanisms. Further, it investigates various techniques that are used for analyzing the genetic polymorphisms. The book contains many chapters which summarize the importance of genetic information obtained from polymorphism-based pharmaco-genetic tests to predict better drug response and life-threatening adverse reactions to chemotherapeutic agents, help in understanding of the impact of SNPs on gene function, and gives overview of the different SNP databases for examination. This book, therefore, serves as an essential guidebook for independent researchers as well as institutions working in this specialised field.

This is the fourth book which I have put forth with utmost hard work and in depth coverage. This book has been ideated to help the students understand the basic concepts of Molecular Biology and Bio- techniques. This book is written mostly from the viewpoint of the basic scientist who works at the cellular and molecular level. As molecular biology is one of the fore front subjects in research and development these days, it has become almost necessary for the students to have a hold on this subject. Coupled with the molecular biology are the bio-techniques employed in every walk of research. A student aspiring to be a researcher needs to have a fair knowledge of the basic lab techniques used in R&D. Written in lucid language so as to be easy for the beginners reading these two subjects for the first time, it comprises of two units, each of which have been written according to the needs of the student at the primary level.

This is the third book which I have put forth with utmost hard work and in depth coverage on each and every aspect of the syllabi. Walking on the path of my last two books I have really tried hard to make the text up to date and competitive and at the same time easy in language so as not to be difficult to learn. This book comprises of nineteen chapters, each of which has been kept according as the syllabi demanded, however I have explained each and every topic in depth which I could have afforded, even though it was beyond the scope of this book. The last two chapters have been added to fulfill the need to impart some basic knowledge of research areas.

This book comprises of eight chapters. Each and every chapter has been described in depth which we could have afforded, so as to benefit the student as much as possible. Every topic has been explained in the lucid language. This book is actually a sequel to our previous book "Concepts in Biotechnology." Walking on the same path we have really tried hard to make the text up to date and competitive and at the same time easy in language so as to not be difficult to learn.

The underlying theme of this doctoral thesis was To evaluate the role of genetic aberrations in different signal transducing molecules of important signal transduction pathways that are involved in the development and progression of CRC in Kashmiri population. To assess the possible association between the genetic aberrations of the signal transducing molecules and various life style factors that are likely to lead to the development and progression of colorectal cancer. To observe the significance of multistep model of CRC carcinogenesis in explaining the CRC carcinogenesis in our Kashmiri population. After assessing the various signal transducing molecules for genetic aberrations we found that the multi-step model of CRC carcinogenesis holds well in explaining the CRC tumorigenesis in our Kashmiri population but with a slight difference in manner and frequency of genetic aberrations of key tumor suppressor genes and oncogenes.